Grape Nutritional Therapy Research

Health properties of grapes are investigated in hundreds of research studies. In this small selection, I review investigations of several diseases related to whole grapes, extracts, juice, wine, and vine leaves.

Grape Nutritional Therapy Research Topics

Grape Extract, Diabetes, Blood Pressure, Heart Disease
Tomé-Carneiro, João, Mar Larrosa, María J. Yáñez-Gascón, Alberto Dávalos, Judit Gil-Zamorano, Manuel Gonzálvez, Francisco J. García-Almagro, José A. Ruiz Ros, Francisco A. Tomás-Barberán, and Juan Carlos Espín. 2013. “One-Year Supplementation with a Grape Extract Containing Resveratrol Modulates Inflammatory-Related MicroRNAs and Cytokines Expression in Peripheral Blood Mononuclear Cells of Type 2 Diabetes and Hypertensive Patients with Coronary Artery Disease.” Pharmacological Research 72 (72): 69–82.

Conclusion: long-term supplementation with a grape extract [is beneficial in] T2DM [diabetic] hypertensive [high blood pressure] patients with stable CAD [coronary artery disease] and treated according to accepted guidelines for secondary prevention of CVDs [cardiovascular diseases]

Grape Fiber and High Cholesterol
Jiménez, Jara Pérez, Jose Serrano, Maria Tabernero, Sara Arranz, M. Elena Díaz-Rubio, Luis García-Diz, Isabel Goñi, and Fulgencio Saura-Calixto. 2008. “Effects of Grape Antioxidant Dietary Fiber in Cardiovascular Disease Risk Factors.” Nutrition 24 (7): 646–53.

Conclusion: Grape antioxidant dietary fiber showed significant reducing effects in lipid profile and blood pressure. The effects appear to be higher than the ones caused by other dietary fibers, such as oat fiber or psyllium, probably due to the combined effect of dietary fiber and antioxidants.

Grape Seed Extract and Tooth Decay
Wu, Christine D. 2009. “Grape Products and Oral Health.” Journal of Nutrition 139 (9).

Conclusion: Grape seed extract, high in proanthocyanidins, positively affected the in vitro demineralization and/or remineralization processes of artificial root caries lesions

Grapes, Diabetes, and Heart Disease
In addition to the conclusion, this study notes that grape consumption is interesting due to “antioxidant, cardio-protective, anticancer, anti-inflammation, anti-ageing and antimicrobial properties”.
Rasines-Perea, Zuriñe, and Pierre Louis Teissedre. 2017. “Grape Polyphenols’ Effects in Human Cardiovascular Diseases and Diabetes.” Molecules 22 (1): 68.

Conclusion: This is a comprehensive review on the consumption of polyphenolic grape compounds, concerning their potential benefits for human health in the treatment of cardiovascular diseases and diabetes.

Whole Grape or Extracts?
Whole grapes are beneficial in early disease stages and prevention. But for advanced diseases, extracts are better.
Singh, Chandra K., Xiaoqi Liu, and Nihal Ahmad. 2015. “Resveratrol, in Its Natural Combination in Whole Grape, for Health Promotion and Disease Management.” Annals of the New York Academy of Sciences 1348 (1): 150–60.

whole-grape products may help in maintaining heart health and protect against aging, aging-associated diseases, neurodegeneration, and some cancers. […] However, for advanced disease conditions, individual grape ingredients (such as resveratrol) or the combination of multiple ingredients, together with existing therapies, appears to be a better approach.

Vine Leaves Extract and Stomach Inflammation
Sangiovanni, E., C. Di Lorenzo, E. Colombo, F. Colombo, M. Fumagalli, G. Frigerio, P. Restani, and M. Dell’Agli. 2015. “The Effect of in Vitro Gastrointestinal Digestion on the Anti-Inflammatory Activity of Vitis Vinifera L. Leaves.” Food & Function 6 (8): 2453–63.

Conclusion: water extracts from Vitis vinifera L. leaves could be useful to inhibit/attenuate gastric inflammation

Grape Juice or Wine for Diabetes?
Banini, Akpene E., Leon C. Boyd, Jonathan C. Allen, Hengameh G. Allen, and Derrick L. Sauls. 2006. “Muscadine Grape Products Intake, Diet and Blood Constituents of Non-Diabetic and Type 2 Diabetic Subjects.” Nutrition 22 (11): 1137–45.

Conclusion: Daily intake of 150 mL of MW [muscadine grape wine] or Dz-W [dealcoholized muscadine grape wine] with meals improved several metabolic responses among diabetics compared with diabetics given MJ [muscadine grape juice].

Grape Nutritional Therapy Research Summary

This sample of grape studies show benefits for many diseases. Including aging, blood pressure, cancer, cholesterol, diabetes, heart disease, and tooth decay. Also, there are many more studies covering these and other diseases.

Grapes, Juice, Wine, and Vine Leaves

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